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  • Tadalafil has a half-life of around 17.5 hours, influencing dosing.
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Do not split, break, chew, or crush it.

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  • Maximum dosing frequency is once per day for the daily formulation.
  • It may improve exercise capacity in some men with pulmonary arterial hypertension (off-label).
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Medication Type Interaction Effect Notes
Nitrates Severe hypotension Do not combine with Cialis
Alpha-blockers Increased risk of low blood pressure Consult doctor for dose adjustments
CYP3A4 Inhibitors Increased tadalafil levels Use lower doses or avoid combination
Other ED drugs Possible additive effect Risk of priapism; caution advised

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